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Date: Sat, 05 Dec 2020 04:45:23 GMT
Only 3 cases of coronavirus disease 2019 (COVID-19) were identified in Italy in the first half of February 2020 and all involved people who had recently traveled to China. On February 20, 2020, a severe case of pneumonia due to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) was diagnosed in northern Italy’s Lombardy region in a man in his 30s who had no history of possible exposure abroad. Within 14 days, many other cases of COVID-19 in the surrounding area were diagnosed, including a substantial number of critically ill patients.1 On the basis of the number of cases and of the advanced stage of the disease it was hypothesized that the virus had been circulating within the population since January.
Another cluster of patients with COVID-19 was simultaneously identified in Veneto, which borders Lombardy. Since then, the number of cases identified in Italy has rapidly increased, mainly in northern Italy, but all regions of the country have reported having patients with COVID-19. After China, Italy now has the second largest number of COVID-19 cases2 and also has a very high case-fatality rate.3 This Viewpoint reviews the Italian experience with COVID-19 with an emphasis on fatalities.
At the outset of the COVID-19 outbreak, the Italian National Institute of Health (Istituto Superiore di Sanità [ISS]) launched a surveillance system to collect information on all people with COVID-19 throughout the country. Data on all COVID-19 cases were obtained from all 19 Italian regions and the 2 autonomous provinces of Trento and Bozen. COVID-19 cases were identified by reverse transcriptase–polymerase chain reaction (RT-PCR) testing for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The fatality rate was defined as number of deaths in persons who tested positive for SARS-CoV-2 divided by number of SARS-CoV-2 cases. The overall fatality rate of persons with confirmed COVID-19 in the Italian population, based on data up to March 17, was 7.2% (1625 deaths/22 512 cases).3 This rate is higher than that observed in other countries2 and may be related to 3 factors.
The demographic characteristics of the Italian population differ from other countries. In 2019, approximately 23% of the Italian population was aged 65 years or older. COVID-19 is more lethal in older patients, so the older age distribution in Italy may explain, in part, Italy’s higher case-fatality rate compared with that of other countries. The Table shows the age-specific fatality rate in Italy compared with that of China.4
The overall case-fatality rate in Italy (7.2%) is substantially higher than in China (2.3%). When data were stratified by age group, the case-fatality rate in Italy and China appear very similar for age groups 0 to 69 years, but rates are higher in Italy among individuals aged 70 years or older, and in particular among those aged 80 years or older. This difference is difficult to explain. The distribution of cases is very different in the 2 countries: individuals aged 70 years or older represent 37.6% of cases in Italy and only 11.9% in China. In addition, a relevant number of cases in Italy are in people aged 90 years or older (n = 687), and this age group has a very high fatality rate (22.7%); data on cases in those aged 90 years or older were not reported in China. In addition, the report from the WHO-China Joint Mission on Coronavirus Disease 2019 Mortality, which presents data on 2114 COVID-19 related deaths among 55 924 laboratory-confirmed cases in China, reported a fatality rate among patients aged 80 years or older that was similar to the rate in the Italian sample (21.9% in China vs 20.2% in Italy).5
n. 部分，份，命运，分担的责任在苹果(Apple)的蒂姆库克(Tim Cook)支持AR后，该技术可能是更大的机遇。苹果最新操作系统及新款手机iPhone X纳入了AR技术。
Manal al-Sharif is best known for challenging laws and mores that keep women down in her native country.Released in 2013, The Bling Ring is a satirical crime drama that chronicles the adventures of Hollywood Hills high schoolers who burgle the homes of local celebrities. The teens break into homes of icons like Megan Fox and Paris Hilton, stealing cash, clothes, handbags, and jewelry to help them emulate the excessive lifestyles they admire in magazines. The students are eventually caught and sent to jail after posting pictures of their hauls on social media.Average age: 36 for English blended programjewelry2. Marc Faber's Doomsday warning on Bernanke's disastrous QE scheme周一晚间，安卡拉方面证实，不欢迎荷兰驻土耳其大使返回土耳其。是否有什么事情我一直放不下？我们不会总是能意识到我们在何时抓住有害但感觉安全熟悉的事情不放手，不论是一份不称心的工作，还是一段不健康的关系或者一种停滞不前的生活方式。看看你是否执着于对你没用的事情，想出小措施来改变和解脱吧。
We will promote coordinated urban development above and below the ground, and begin construction on at least another 2,000 kilometers of underground utility tunnels in cities. A three-year initiative will be launched to remove the risk of flooding in highly vulnerable urban areas; and further progress will be made in the development of sponge cities. All these efforts will make our cities more attractive and function better.这一发现引起了历史学家的极大关注，因为这为了解理查三世提供了更加确凿的证据。理查三世于1485年死于博斯沃思战役，之后有关他的一生一直充满争议。14. 另一方面。下面是一份今年大制片公司发行，由女导演执导的粗略名单：华纳兄弟五部！包括拉娜·沃卓斯基(Lana Wachowski)、安妮·弗莱彻(Anne Fletcher)、黛娜·纳彻曼(Dana Nachman)、南希·迈耶斯(Nancy Meyers)和派翠西亚·莱根(Patricia Riggen)。环球影业三部，包括萨姆·泰勒·约翰逊(Sam Taylor Johnson)、伊丽莎白·班克斯(Elizabeth Banks)和安吉丽娜·朱莉(Angelina Jolie)；迪斯尼一部，尼基·卡罗(Niki Caro)。派拉蒙零部。福克斯零部。索尼零部。我没有把福克斯和索尼的独立部门包括进去。这是第二枚被拍卖的诺贝尔和平奖奖牌，得主是第一个获得该奖项的拉美人——1936年诺贝尔和平奖奖牌被授予当年的阿根廷外长卡洛斯·萨维德·拉莫斯。1月份，沃尔玛美国公司总裁兼首席执行官比尔西蒙承诺，这家全球最大零售企业将在今后五年内聘用10万名老兵。此外，作为美国最大的私营雇主，沃尔玛还表示它将邀请光荣退伍不到一年的老兵加盟公司。"I'm not really worried about it, honestly," Bryant said. "My shooting will be better."根据中国海关总署发布的数据，这些进出口贸易使11月中国的贸易顺差比10月的贸易顺差382亿美元提高20亿美元，至402亿美元，远超9月份的6个月低点286亿美元。11月的贸易差额也超过了经济学家预期的350亿美元。She only learnt to walk five months ago, but 'Baby Beyoncé' is already strutting her stuff on stage at pageants.根据报道，当地法院鉴于周某的年龄及其坦白承认自己的罪行，最终给予了周某一个宽大的判决。“即便人们充分了解了（美联储政策的作用），市场动态也可能相对容易地变得不稳定或不利，”他说，“届时你将陷入一个卖盘压力自我强化的循环。”周二在华盛顿DC倒下的大树把一条街拦住了。10. "Arrow" (2.2 million)从2016年6月1日至2017年6月1日，世界上收入最高的十位模特的税前总收入不算各项费用共计为1.095亿美元。然而据北京出入境边防检查总站(Beijing General Station of Exit and Entry Frontier Inspection)称，只有14,000名旅客办理了过境免签手续，远低于官方此前预计的20,000人。
oDesk and Elance (now in the process of merging) are freelance marketplaces, which allow you to quickly identify, engage and hire freelancers from all over the globe. Need a website developer or content writer? Don’t hire an employee; instead, work with a freelancer. At last count, there were more than 1 million freelance contractors available via these marketplaces.Meanwhile, villages within the city's boundaries will be overhauled and low-end manufacturers and logistics companies removed.8.Suicide Squad最糟糕地利用社交媒体奖a朝向，void空－空城计－避开Social scientists, after crunching data from both sides of the Atlantic, have discovered something surprising: it’s not the amount of racial or ethnic diversity in a community that predicts white resentment and support of anti-immigrant policies, but the pace of change.
Having reached the current stage of development, China can now advance only through reform and innovation. We have the largest quality workforce as well as the largest pool of scientists, engineers and professionals in the world, and their potential for innovation is truly tremendous.The Fate of the Furious was the top-grossing foreign film, ranking second on the list.民粹主义的兴起（即使在美国和英国这样的就业人数众多的国家也是如此）使得政客们认识到，就业的质量和数量同等重要。交通运输部科学研究院近日发布的报告显示，北京位居全国十大最拥堵城市排行榜第三，排在济南、哈尔滨之后。单词commercial 联想记忆：adj. 流行的，大众的，通俗的，受欢迎的More advanced components are in short supply, however, which could leave many customers waiting long after September to get hold of the new iPhone. That presents an opportunity for rivals such as Samsung’s new Note 8 or Essential, the smartphone maker led by Android co-founder Andy Rubin, which is targeting premium customers such as Apple’s with its slick $699 device. Google is also said to be preparing a new version of its Pixel smartphone, which has proved popular with early adopters.另一种看法是，油价在过去三年中的变动，是长期结构性变化的开始，预示着下一个50年里，能源价格按实际值计算将显著低于上一个50年。简单地说，持这种看法的人认为，供给的增长潜力超过需求增长。汤森路透2015年全球创新百强名单是基于对专利相关的标准进行深入研究，寻找真正的创新企业。Roles With Bite2013年排名：14China has 731 million Internet users as of December 2016, roughly the size of Europe's population, according to a report released by the China Internet Network Information Center (CNNIC).上证综指下跌6.85%，以科技版块为重点的深证综指下跌8.22%。This year, the average sales price for an apartment in New York City topped $1 million, a milestone with far-reaching implications. As the city’s population soars, prices and buildings are rising in neighborhoods that missed the last housing boom.4. OPEC’s Next Move.OPEC deserves a lot of credit (or blame) for the remarkable downturn in oil prices last year.While many pundits have declared OPEC irrelevant after their decision to leave output unchanged, the mere fact that oil prices crashed after the cartel’s November meeting demonstrates just how influential they are over price swings. For now OPEC – or, more accurately, Saudi Arabia – has stood firm in its insistence not to cut production quotas. Whether that remains true through 2015 is up in the air.译者：清远2.你突然变成Twitter上面思想领军人物。So with such a strong South American contingent, where will the main challenge come from ? Well, the big guns from Europe is the obvious answer. And where else could you look for a team of Champions than Spain. Having won the last World Cup, sandwiched between two European Championship triumphs, this is a team that not only knows how to play fantastic football, but that knows how to win. So whilst Messi and Ronaldo get all the annual plaudits and player of the year titles, the likes of Xavi and Iniesta go about winning all the major trophies. So will they be as string this year ? Well, worryingly for the rest of the world, yes. Not only are most of the old guard still there but talented youngsters such as Koke and Thiago Alcantara have joined the ranks. Not only that, but they've managed to grab a prolific striker, Diego Costa, from under the noses of the host nation, with the Atletico Madrid forward opting to play for Spain, rather than the nation of his birth.
Other countries have different testing strategies. For example, the Republic of Korea has adopted a strategy of widely testing for SARS-CoV-2. This may have led to the identification of a large number of individuals who had mild or limited symptoms, but a much lower case-fatality rate compared with Italy (1.0% vs 7.2%) because many patients with mild disease who would not be tested in Italy were included in the denominator in Korea.2
迁移工程也是京津冀一体化计划的一部分，其目的在于缓解首都交通拥挤，为地区提供更加均衡的发展。伊丽莎白?泰勒和理查德?伯顿的爱情之大银行已经或多或少地放弃了用高薪留住人才的尝试。自金融危机以来，有一件事很清楚：如果你想暴富，就得去硅谷。露丝波拉特(Ruth Porat)在2015年树立了一个标杆，她放弃了摩根士丹利(Morgan Stanley)首席财务官约1300万美元的年薪，跳槽谷歌（如今的Alphabet）获得五倍于此的薪酬。吕特在周一晚间的辩论中重申，他不会与维尔德斯所属的政党组建联合政府，他甚至还表示不可能组建一个依赖这个反移民政党支持的政府。吕特表示：“我不会再次与这样的政党合作。”在2010年选举之后，吕特组建的首个少数派政府受到自由党的支持。Wages will finally accelerate after years of stagnation可以这样说美国银行首席执行官布莱恩?莫尼汉这个人：他很会说话。在给股东的信中，莫尼汉特地感谢美国纳税人，正是由于他们，美国银行才获得了450亿美元的不良资产援助资金。他还说自己如今正在金融改革方面同“政策领导人”紧密合作。不过他是否能做好，比如转变美国银行的境遇，就是另外一回事了。虽然美国银行的确在去年12月偿还了援助资金，但是它仍然有数十亿美元的高风险住房与商用房房贷，这也是为什么它要在年度报告中花8000字来讨论风险了。Artificial pancreas, however, knock insulin into your body automatically. The device looks much like a regular insulin pump, which slips you insulin continuously through your skin, but this one monitors your blood sugar at all times and adjusts itself accordingly. So even when the wearer sleeps, there's no danger of falling into shock if their sugar drops too low.Amy Kazmin“The individual sent an email blast to the entire staff.”
We will ensure that foreign trade continues to pick up and register steady growth.There are two concerns about taking a so-called survival job. It could distract you from your job search, and potential employers may have trouble envisioning you in your previous professional role.但大部分海外岛屿则会出售永久产权。The number of initial public offerings (IPO) and the amount of funds raised in the Chinese mainland's A-share market fell sharply year-on-year during the first half of 2016, according to statistics released by PwC last Monday.与官方PMI指数相比，财新赞助的系列调查的样本是数目少得多的民营企业，其结果的波动性往往更大。而官方PMI指数则主要关注规模更大的国有企业。7. 举重训练可以帮助提高长期记忆力获奖者：侯任总统唐纳德?特朗普和希拉里·克林顿（共同获奖）单词amnesty 联想记忆：今年1月份CPI同比上涨1.8%，去年12月同比上涨为1.6%。不过该指数仍落后于北京方面“3%左右”的目标。法国兴业银行(Societe Generale)国际策略师基特?朱克斯(Kit Juckes)说，过去30年破灭的三个世界级金融大泡沫背后，都是“美联储(Fed)太久时间将政策利率维持在名义经济增长率之下”。
Corresponding Author: Graziano Onder, MD, PhD, Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Via Giano della Bella, 34-0161 Roma, Italy (firstname.lastname@example.org).
Published Online: March 23, 2020. doi:10.1001/jama.2020.4683
Correction: This article was corrected on April 16, 2020, to correct a data error reported in the eighth paragraph (number of women in the subsample was 106).
Conflict of Interest Disclosures: None reported.
Additional Contributions: We thank the following members of the COVID-19 Surveillance Group who were involved in the collection of data used in this report: Xanthi Andrianou, Antonino Bella, Stefania Bellino, Stefano Boros, Marco Canevelli, Maria Rita Castrucci, Alessandra Ciervo, Fortunato D'Ancona, Martina Del Manso, Chiara Donfrancesco, Massimo Fabiani, Antonietta Filia, Cinzia Lo Noce, Alberto Mateo Urdiales, Luigi Palmieri, Patrizio Pezzotti, Ornella Punzo, Valeria Raparelli, Flavia Riccardo, Maria Cristina Rota, Andrea Siddu, Paola Stefanelli, Brigid Unim, Nicola Vanacore.
Every point we think we've reached where James cannot be better than he has been, he then blows past it like a poor center switched onto him. What will be discussed most is his all-encompassing skill, but this is also a testament to the work that James puts in. You can mock all those Instagram videos he puts up, but those are the real reason he's still able to do this; James has never cheated the game, not a day in his life, and the result is incomparable performance night in and night out.
“The US economy is likely to grow by 3 per cent plus this year as well as next year.但并非所有记者──比如笔者本人──都认同这个最终评估结果。Call Me By Your Name达福目前可能是最佳男配角的领跑者。The report by iResearch Consulting Group and Sina Weibo, China's most popular microblogging platform, was released at a forum in Shanghai, co-organized by Weibo and telecom giant Huawei .2. “Inside Out” (Pete Docter)
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Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA. 2020;323(18):1775–1776. doi:10.1001/jama.2020.4683
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