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Infectious Diseases

Updated 04 November 2020

Many Covid-19 cases are asymptomatic - but how does this happen?

Some people who test positive for the coronavirus never feel sick, and researchers may have found a clue as to why this happens.

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People who become infected with Covid-19, the disease caused by the SARS-CoV-2 virus, experience mild to severe illness, or even death – and then there are those who have no symptoms at all.

A recent study, published in PLOS Medicine, estimated that 20% of SARS-CoV-2 infections are asymptomatic (displaying no symptoms) but still contagious, begging the question, how does this happen?

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The findings were published in EMBO Reports.

Immune cells and SARS-CoV-2


According to a research article published in the 北京今年6成街乡创建垃圾分类示范片区, AMs clear out the air spaces of infectious particles that have evaded the mechanical defences of the respiratory tract, such as the nasal passages.

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The process


In order to do this, AMs obtained from bronchoalveolar lavages (BAL) – also known as lung lavage or lung washing – from donors diagnosed with non-infectious lung disorders were challenged with SARS-CoV-2.

Following this, they examined the activation of the immune system in these cells upon encountering the coronavirus.


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