L-glutamine may alter gut microbiota to resemble changes seen in weight loss programs

By Stephen Daniells

- Last updated on GMT

L-glutamine may alter gut microbiota to resemble changes seen in weight loss programs

Related tags: Gut microbiota, Obesity

Supplements of L-glutamine may alter the composition of the gut microbiota in obese people, and shift it towards a profile seen in leaner individuals, says a new study from Brazil.

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这份排行榜衡量的是商学院研究生课程的质量和广度。它基于相关商学院在英国《金融时报》每年发布的4个主要榜单上的表现:MBA、EMBA、管理硕士和高管教育。只有参与所有这4项排名的商学院才有资格获得满分。
Beijing has responded with increasing rancour against Seoul’s decision to deploy Thaad, the Terminal High Altitude Area Defence platform. While South Korea insists the system is for defending itself against North Korean missiles, China fears the technology will allow an ally of the US to spy on its military developments.
中国商务部的最新数据不包含个人购买的房地产。有不少个人利用中国资本管制体系的漏洞来获取外汇。但外汇监管机构最近采取措施堵住了此类漏洞,尤其是收紧了对个人购汇的管控——按现行规定,中国公民每年可用人民币购买等值5万美元外汇。

“The finding that L-glutamine promotes changes in the gut microbiota composition provides support for the importance of some nutrients in modulating the intestinal bacterial profile,”​ wrote the researchers in Nutrition​. “These changes resembled the weight loss programs established in the literature.”

Gut health and obesity

澳大利亚一名女子将其猫咪们遗弃在家里,最后这些猫咪们竟同类相食,目前该女子已被判虐待动物罪。

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One year later and Dr Gordon’s reported similar findings in humans: The microbial populations in the gut are different between obese and lean people, and that when the obese people lost weight their microflora reverted back to that observed in a lean person, suggesting that obesity may have a microbial component (Nature​, Vol. 444, pp. 1022-1023, 1027-1031).

A more recent paper from the same group in Science Translational Medicine​ (Vol. 3, 106ra106) reported that ingestion of probiotic bacteria produced a change in many metabolic pathways, particularly those related to carbohydrate metabolism.

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但是,是什么推动了乐观或悲观情绪呢?库迪斯与巴塞罗那庞培法布拉大学(Universitat Pompeu Fabra)的汉斯-乔亚吉姆o沃斯发现了一些令人意外的答案。
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The Brazilian researchers did not observe any changes in body weight during their 14 day study, but noted that a longer intervention period “may result in metabolic changes”​.

Study details

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By the end of 2015, Shanghai's population of migrant residents had decreased to 9.8 million, comprising 40.6 percent of the city's roughly 24 million permanent residents, according to statistics released by the Shanghai Municipal Statistics Bureau on Monday.
2016年国家公务员考试报名人数已经超过去年,仅周二一天,符合考试条件的报考人员就达到13.2万人以上,这是单日报考人数最高的一天。

“Thus, these findings suggest that oral supplementation of L-glutamine have similar effects on gut microbiota as weight loss,” ​said the researchers. “We would like to highlight that although the age range of the volunteers was large (23-59 y) and aging may have an effect on intestinal microbiota, the results obtained in this study were statistically significant.”

Commenting on a potential mechanism, they noted that L-Glutamine supplementation may reduce pro-inflammatory cytokines. “Some bacteria genera are associated with gut inflammation,”​ they wrote. “For example, increased levels of ​Veillonella are associated with higher levels of gut inflammation and the development of colitis and Crohn's disease. In our study, the number of bacteria from the ​Veillonella genus reduced after L-glutamine supplementation, suggesting that L-glutamine may have an anti-inflammatory effect, at least in part, due to the decrease of this genus.

“In addition, increased abundance of the ​Prevotella genus has been described as a shield against inflammation and non-infectious diseases of the colon. After L-glutamine supplementation, but not after alanine, we observed an increase in ​Prevotella, suggesting that L-glutamine may have a protective effect on the gut via modulation of bacteria.”

Source: Nutrition
Published online ahead of print, doi: 10.1016/j.nut.2015.01.004
“Oral Supplementation with L-Glutamine Alters Gut Microbiota of Obese and Overweight Human Adults: A Pilot Study”
Authors: A.Z.Z. de Souza, A.Z. Zambom, K.Y. Abboud, et al.

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